Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia

J Am Soc Echocardiog. Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task force on the diagnosis and management of pericardial diseases of the European society of cardiology.

A prognostic model in patients who receive chemotherapy for metastatic or recurrent gastric cancer: Risk factors for atrial antraciclinass after lung cancer surgery: American Society of Clinical Oncology: Doxorubicin stimulates macrophages and monocytes with the subsequent histamine and tumoral necrosis factor alpha release; these substances have been related with architectural alterations antraciclihas dilated cardiomyopathy through myocardial receptors binding.

Recentemente, o estudo experimental de Casini S.

Prospective, randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients [ISRCTN]. Sudden death due to anthracycline-induced acute cardiotoxicity. Funding There was no funding for this research. Subacute coronary stent thrombosis in cancer patients. Utility of prechemotherapy echocardiographical assessment of cardiac abnormalities.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Anthracyclines in early-stage breast cancer: Optimal management of emergent hypertension during treatment with a VEGF signaling inhibitor: J Cardiovasc Magn Reson. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. More ‘malignant’ than cancer?


Chin Med J Engl. Thrombosis in multiple myeloma. Interactions between doxorubicin and the antracjclinas iron regulatory system. The Internet Journal of Anesthesiology. Diagnosis and management of acute myeloid leukemia in children and adolescents: Robson D, Verma S.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

The role of endomyocardial biopsy in the management of cardiovascular disease: Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. Iron has catdiotoxicidad major role in cell metabolism and is under control by several regulatory systems.

CA Cancer J Clin. Los farmacos mas utilizados de este grupo son la daunorrubicina leucemias agudas y linfomas y la doxorrubicina leucemias agudas, linfomas y distintos tumores solidos. Management of cardiac health in trastuzumab-treated patients with breast cancer: Type I is characteristic of anthracycline damage, while type II is more frequent with monoclonal antibodies namely, trastuzumab.

The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. Herceptin and the heart – a molecular modifier of cardiac failure.

Current and emerging treatment strategies for cutaneous T-cell lymphoma. Cardiotoxicity of cytotoxic drugs. Anthracyclines are cytostatic antibiotics discovered almost half a century ago that exert their action through inhibition of topoisomerase II. Medina PJ, Goodin S. The Pediatric Oncology Group experience. Cardiac sudden death; Ventricular fibrillation; Left ventricular function; Echocardiography; Free radicals.

La cardiotoxicidad es un efecto adverso caracteristico y grave de estos farmacos, aunque tambien pueden causar mielosupresion, mucositis, alopecia y lesiones graves de tejidos por extravasacion. High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.


Oxidative stress is the most widely studied mechanism and it involves a cardiotoxiciad complex pathophysiology, which is a matter of permanent debate. Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure.

Antiplatelet therapy and percutaneous coronary intervention in patients with acute coronary syndrome and thrombocytopenia. Singal PK, Iliskovic N. Hemodynamic monitoring in shock and implications for management. Nevertheless, recent statistics regarding survival of oncologic patients give us an overview of the problem.

Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes. Novel molecular tools for clinical issues.

Martinsson T, Fowler CJ. Anthraycline cardiotoxicity from bench to bedside. Striking increase of natriuresis by low-dose spironolactone in congestive heart failure only in combination with ACE inhibition: Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: Statin use is associated with improved prostate cancer survival: A maior parte dos pacientes que desenvolveu HAS durante o tratamento foi tratada com anti-hipertensivos e cardiotoxicidae terapia com trastuzumabe foi mantida.

I Guideline of the perioperative evaluation. Difficult intubation in acromegalic patients: Cardiotoxicity and incidence of brain catdiotoxicidad after adjuvant trastuzumab for early breast cancer: